Autopsy Report
Ch. Timbe Good News Of Luke
August 24, 1992-May 24, 1998
DIAGNOSIS AND COMMENTS (6/15/98)
Pannicultis, retropharyngeal lymphadenitis, necrosupportive
Multiple site hemorrhagic, possible Disseminated Intravascular Coagulation (DIC)
Severe and chronic interstitial nephritis with mineral casts
COMMENTS
No amyloid material are noted in routine sections and special stain. The cause of death has been attributed to a DIC possibly associated with the acute inflammation involving retropharyngeal lesions. No amyloid has been identified in the kidney, however, the chronic renal disease may have predisposed the dog to a coagulation disorder.
Gross Findings
The carcass is that of an adult male brown colored Shar-Pei dog. The carcass is deeply frozen. Upon thawing major gross findings include extensive subcutaneous edema and hemorrhagic infraction involving the retropharyngeal area, portion of the parotid gland on the left side and ventral neck area. The lymph nodes are markedly hemorrhagic and enlarged. Marked discolorations and hemoglobin staining and disruption of tissues from the ice crystal build-up compromised interpretation of gross lesions. Of significance, is numerous recently formed thrombi occluding major vessels of head, neck, and thorax, particularly the brachiocephalic left common carotid and hypoglossal arteries. Within the substance of the lung, major vessels are similarly occluded by recently formed thrombi. Other than dark black discolorations of the liver, spleen and kidney and multiple wedge shaped and confluent areas of chronic infarction and fibrosis of renal cortex with adherent renal capsule no significant lesions are noted elsewhere.
Histopathology
Kidney: There are multiple wedge shaped areas of cortical collapse with marked fibrosis, chronic inflammation and mineral cast occluding renal tubules. Intervening renal parenchyma also contain scattered mixed inflammatory cells and fibrosis. Additional sections of kidney feature marked mineralization and fibrosis as well.
Lung: Widespread areas of congestion, atelectasis and multiple hemorrhagic thrombi occluding vessel lumen are notable features. Additionally marked peribronchiolar and perivascular edema are present.
Subcutaneous Tissue Involving Ventral Neck: Extensive areas of panniculitis, fat necrosis and suppurative inflammation are noted.
Heart: Unremarkable
Retropharyngeal Lymph Node: Marked congestion, edema and hemorrhage as well as severe freezing artifactuous changes present. Large areas of hemorrhage, hematoma as well as hemorrhagic thrombi are prominent features.
Due to postmortem changes/freezing artifact, interpretation of intestine, brain, and other organ systems are rendered difficult.
Bacteriology
Lymph Node: streptococcus spp, alpha hemolytic; streptococcus spp, non-hemolytic; bacillus spp; no anaerobes isolated.
Necropsy performed by: Dr. Monty Banerjee, DVM, PhD
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